Professor of Biomedical Engineering
Professor of Ophthalmology & Visual Sciences
Ph.D., Bioengineering, University Of Pennsylvania -1981
PA. B.A., Mathematics, Haverford College -1969
We seek to develop technologies for diagnostic and research applications at the nano and molecular level using both in vitro and in vivo systems. Our laboratory has a strong collaborative and experimental focus as indicated by the current examples listed below.
“Coffee Ring Diagnostics for Malaria” – The goal of this Gates Foundation funded project (with David Wright in Chemistry) is to develop a low-cost & simple diagnostic device for the detection of malaria suitable for low resource environments. Our current design uses the presence of a malarial biomarker to alter the microfluidic transport of particles in an evaporating drop and produce visually detectable changes in particle ring formation.
"Multi-spectral quantum dot-based retinal imaging of molecular expression in vivo" – The unique optical properties of quantum dots offer the potential for new optical methods to study molecular events. This NIH funded project (with Ash Jayagopal in Chemistry and John Penn in Ophthalmology) seeks to develop a platform for the real-time, in vivo analysis of multiple cellular and molecular events in vivo using quantum dot nanocrystals and retinal fluorescence microscopy.
"Retinal imaging of prognostic indicators of atherosclerosis" – This quantum dot NIH funded project (with Sergio Fazio in Cardiovascular Medicine & Ash Jayagopal in Chemistry) seeks to use novel retinal imaging agents as a tool to predict the progression of atherosclerotic lesions in coronary arteries.
"Development of DNA Logic Operations for Viral Diagnostics" - The goal of this NIH funded project (with David Wright in Chemistry, Jim Crowe in the Medical Center) is to develop and evaluate a new paradigm in virus detection. The approach is based on a combination of nanoparticle surface chemistry, tag-specific DNA sequences, and DNA ligation logical AND operators.
"The role of Bves in the human cornea" – In this NIH funded project (with Min Chang in Ophthalmology) our long term objectives are to understand the role of the junction protein Bves, and more broadly, the molecular basis of corneal regeneration both in homeostasis and wound repair. Our central hypothesis is that Bves is important in corneal epithelial cellular migration and proliferation mediated through regulation of adhesion junctions.
Russ PK, Pino CJ, Haselton FR, Chang M, Bves Modulates Tight Junction Associated Signaling, Plos One 6(1):e14563; PMCID 3024319, 2011.
Williams, C.S., Zhang, B., Smith, J., Jayagopwl, A., Barrett, C.W., Pino, C., Russ, P., Presley, S.H., Peng, D. Rosenblatt, D.O., Haselton, F.R., Yang, J.L., Washington, M.K., Chen, X. Eschrich, S. Yeatman, T.J., El-Rifai, W., Beauchamp, R.D. and Chang, M.S., BVES regulates EMT in human corneal and colon cancer cells and is silenced via promoter methylation in human colorectal carcinoma, J Clinical Invest 121(10):4056–4069, 2011. doi:10.1172/JCI44228.
Perez, JW, Vargis, EA, Russ, PK, Haselton, FR and Wright, DW, Detection of respiratory syncytial virus using nanoparticle amplified immuno-PCR Analytical Biochemistry 410(1): 141-8, 2011.
Ashwath Jayagopal, Jin-Long Yang, Frederick R Haselton, and Min S Chang, Tight junction-associated signaling pathways modulate cell proliferation in uveal melanoma, Invest. Ophthalmol. Vis. Sci. 52(1): 599-93, 2011.
Bordelon, H., Adams, N., Klemm, A.S., Russ, P.K., Williams, J.V., Keipe, H.K., Wright, D.W. and Haselton, F.R., Development of a low resource RNA extraction cassette based on surface tension valves. ACS Applied Materials & Interfaces 3:2161-2168, 2011.
Adams, Nicholas M., Jackson, Stephen R., Haselton, Frederick R., Wright, David W., Design, Synthesis and Characterization of Nucleic Acid-Functionalized Gold Surfaces for Biomarker Detection, Langmuir Sep 28, 2011), PMID 21905721.
Swartz, J.D., Gulka, C.P., Haselton, F.R. and Wright, D.W. Colorimetic diagnostic using Ni(II)NTA functionalized Au and Ag nanoparticles, Langmuir 27(24):15330-15339, 2011, PMID 22026818.
Trantum, J.A., Wright, D.W., Haselton, F.R. Biomarker-Mediated Disruption of Coffee-Ring Formation as a Low Resource Diagnostic Indicator, Langmuir Dec 9, 2011, PMID 22148855.