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ISIS is an academic/professional research institute established by the Vanderbilt University School of Engineering in 1998 and located just off campus on Nashville's Music Row. Our work focuses on systems, with deeply integrated software that are networked, embedded, and cyber-physical.

Annual funding is $20+ million, and there are active projects with dozens of academic and industry collaborators at Vanderbilt, other leading universities, and companies in the U.S. and around the world. ISIS employs 80+ research scientists and staff engineers, 11 electrical engineering/computer science faculty, six administrative staff members, and 40+ graduate students.

We conduct cutting-edge, world-class research on real-world problems in the following areas:

  • Model-Integrated Computing
  • Model-based design automation for software
  • Modeling techniques and tools—visual and textual
  • Model transformations and model management
  • Model-based verification of systems and software
  • Design-space exploration, generative design
  • Model and tool integration
  • Semantic foundations for models and modeling

Distributed Real-Time and Embedded Systems

  • Adaptive and reflective middleware
  • Model-based integration technology
  • Secure and fault-tolerant middleware
  • Middleware for mobile devices

Wireless Sensor Networks

  • Operating software for wireless sensor networks
  • Radio-interferometric sensor localization
  • Applications: shooter location, infrastructure monitoring, and many others

Model-Based Design of Cyber-Physical Systems

  • Design of systems where classical engineering meets computing: vehicles, robots, etc.
  • Verification and high-confidence design
  • Model-based manufacturing
  • Model-based system integration of CPS

Systems Security and Privacy

  • Privacy-aware health information systems
  • Foundations for resilient systems design
  • System security co-design
  • Secure control systems for industry and society

Learn more about all ongoing ISIS projects at