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‘cancer immunotherapy’

Like geese and race cars, cancer cells draft their way to new sites

Mar. 25, 2019—Finding gives boost to fighting through cell metabolism NASCAR has nothing on cancer cells when it comes to exploiting the power of drafting, letting someone else do the hard work of moving forward while you coast behind. Building on the relatively new discovery that metastatic cancer cells leave tumors and travel in clusters, not singles,...

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Nanoparticle targets tumor-infiltrating immune cells, flips switch telling them to fight

Jan. 21, 2019—New research builds on Nobel-winning immune checkpoint blockade work Immunotherapy’s promise in the fight against cancer drew international attention after two scientists won a Nobel Prize this year for unleashing the ability of the immune system to eliminate tumor cells. But their approach, which keeps cancer cells from shutting off the immune system’s powerful T-cells...

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Research team documents potential new treatment path for breast cancer

Jan. 13, 2019—Immunotherapies that take off the “brakes” on the adaptive anti-tumor response have worked well in melanoma and lung cancer but less so in breast cancers. That could change. A Vanderbilt team led by John Wilson, assistant professor of chemical and biomolecular engineering, and Rebecca Cook, associate professor of cell and developmental biology, activated innate immunity...

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Novel, ‘multiplexed’ diagnosis may better identify candidates for cancer immunotherapy

Aug. 26, 2018—A Vanderbilt engineering researcher has shown that combining an enhanced vibrational spectroscopy technique with tagged gold nanostructures can detect important tumor immunomarkers – a significant step toward predicting which patients would benefit from immunotherapy. The study by Rizia Bardhan, assistant professor of chemical and biomolecular engineering, involved breast tumors but the work has broader relevance....

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Bardhan awarded prestigious career development grant for melanoma research

Mar. 23, 2018—A chemical and biomolecular engineering professor has received a prestigious Congressionally Directed Medical Research Programs (CDMRP) Career Development Award to develop an innovative multi-modal imaging platform for melanoma diagnosis and treatment evaluation. Assistant Professor Rizia Bardhan will use novel immunoactive gold nanostructures (IGNs) in conjunction with PET scanning and Raman spectroscopy to assess tumor immunomarkers...

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ChBE research assistant has ‘a good run,’ wins 4 Jeopardy! shows

Dec. 13, 2017—What was a week’s worth of Jeopardy! episodes for the viewing public in fact took place over one, long, grueling day. Kyle Becker, a School of Engineering research assistant, won his first match, then the second, then the third – all before lunch. A 20-minute break between tapings allowed for changing clothes and fixing makeup....

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PhD student wins summer grant to study potential vaccine for pediatric neuroblastoma

Jul. 5, 2017—A grant from cancer research nonprofit Alex’s Lemonade Stand Foundation is allowing a Vanderbilt chemical engineering doctoral student to advance his research on a potential vaccine against pediatric neuroblastoma. Kyle Garland is spending his summer on a project titled Immunotherapeutic Targeting of the STING Pathway to Combat Neuroblastoma. He’s working with John Wilson, assistant professor...

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Engineering researcher wins Stand Up to Cancer award for ‘smart’ nanoparticles

Apr. 4, 2017—John Wilson, assistant professor of Chemical and Biomolecular Engineering and of Biomedical Engineering, has received an Innovative Research Grant from Stand Up To Cancer (SU2C). (photo by John Russell) An assistant professor of Chemical and Biomolecular Engineering and of Biomedical Engineering has received an Innovative Research Grant from Stand Up To Cancer (SU2C). John Wilson,...

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