Skip to main content

‘I-Wire Heart-on-a-Chip’

New tissue-chip research to assess efficacy of novel epilepsy drugs

Sep. 22, 2017—An interdisciplinary team of Vanderbilt University researchers led by John Wikswo, A.B. Learned Professor of Living State Physics and Gordon A. Cain University Professor, has received a two-year, $2 million federal grant to develop an “organ-on-chip” model for two genetic forms of epilepsy. These disorders affect both brain and heart and improved modeling could lead to new...

Read more


Organ-on-a-chip mimics heart’s biomechanical properties

Feb. 23, 2017—John Wikswo with image of the I-Wire heart-on-a-chip device projected behind him. (Joe Howell / Vanderbilt) The human heart beats more than 2.5 billion times in an average lifetime. Now scientists at Vanderbilt University have created a three-dimensional organ-on-a-chip that can mimic the heart’s amazing biomechanical properties. “We created the I-Wire Heart-on-a-Chip so that we...

Read more