Assessing brain microstructure using MRI
Brief Description of Project:
This project will study the biological correlates of diffusion MRI of the brain. Specifically, MRI measurements of water diffusion in brain tissue will be correlated with tissue microstructure imaged with optical microscopy. The goal is to discover quantitative relationships between water diffusion in neuronal fibers and the density, myelination, and coherence of axons within the fibers. This information will help to inform the interpretation of MRI brain scans.
Proficiency in MATLAB programming will be helpful, although not necessary.
Nature of Supervision:
The successful candidate will be supervised by Drs. Anderson and Schilling. Research meetings to discuss progress and results will take place more than once a week at the outset, perhaps becoming less frequent (down to 1 meeting per week) as the summer progresses, depending on project needs.
A Brief Research Plan (period is for 10 weeks):
Week 1: Introduction to the lab, the project, and background reading.
Week 2: Learning the MRTrix3 software package.
Week 3: Analyzing human brain data using MRTrix3
Week 4: Analyzing nonhuman primate brain data using MRTrix3
Week 5: Preparing tissue sections for microscopy
Week 6: Micrograph acquisition
Week 7: Measuring biophysical properties from tissue section microscopy
Week 8: Spatially registering MRI and microscopy data
Week 9: Correlating MRI and microscopy data
Week 10: Wrapping up and preparation of research poster
Number of Open Slots: 1
Name: Adam Anderson
Department: Biomedical Engineering