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Ultrasound cavitation for cancer therapy and imaging

Primary Investigators:
Charles Caskey, Craig Duvall
 
Brief Description of Project:
Focused ultrasound is a non-invasive method of applying acoustic energy into the body to treat medical disorders, such as cancer or movement disorders. Ultrasound is an appealing alternative to surgery because it does not require an incision. In addition to removing tissue via thermal ablation, the energy of ultrasound can also be used to activate drugs in a local region. In this collaborative project between the Caskey and Duvall laboratories, we are developing particles that can act as drug delivery vehicles that are quiescent until ultrasound interacts with them. This capability would have unique benefits in scenarios where drug release is not desired until it reaches its target, such as chemotherapy.

Desired Qualifications:
Dual interest in bench lab work and signal analysis is highly desirable.
 
Nature of Supervision:
The student will work directly with a graduate student and PI.
 
A Brief Research Plan (period is for 10 weeks):
Weeks 1-2: Literature review of focused ultrasound drug delivery and learn procedures to create particles
Weeks 3-5: Apply ultrasound to particles and learn image reconstruction
Weeks 6-9: Analysis of data and refinement of experimental procedures
Week 10: Lab presentation and documentation 

Number of Open Slots: 1
 
Contact Information:
Name: Charles Caskey
Department: Biomedical Engineering
Email: charles.f.caskey@vanderbilt.edu