Skip to main content

Development of a handheld laser speckle contrast imaging system for thyroid surgical guidance

Primary Investigators:
Anita Mahadevan-Jansen
 
Brief Description of Project:
As much as 50% of thyroidectomies result in post-surgical hypoparathyroidism and consequent hypocalcemia due to accidental removal of the parathyroid glands or damage to their blood supply during operation. Laser speckle contrast imaging (LSCI) is able to accurately assess the perfusion state of a parathyroid intraoperatively. However, work to date has involved large cameras at a fixed distance from the patient, making it difficult to image parathyroid glands not directly beneath the surgical incision. This project will involve designing and developing a handheld LSCI instrument to allow access to these glands. Algorithms will be developed to account for motion due to the operator.

Desired Qualifications: 
Proficiency with MatLab or LabVIEW
Image processing experience 

Nature of Supervision:
Student will be directly supervised by Primary Investigator and her graduate students.
 
A Brief Research Plan (period is for 10 weeks):
Week 0-2: Hands on training in LSCI systems
Week 2-5: Development of handheld LSCI system and user interface
Week 3-7: Research and development of motion correction algorithms
Week 6-8: Perfusion phantom imaging and validation experiments
Week 8-9: Quantitative data analysis
Week 9-10: Compile data, summarize results, submit abstract for relevant conference 

Number of Open Slots: 1
 
Contact Information:
Name: Anita Mahadevan-Jansen
Department: Biomedical Engineering
Email: anita.mahadevan-jansen@vanderbilt.edu