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Role of non-enzymatic post-translational modifications in osteoporosis

Primary Investigators:
Jeff Nyman
 
Brief Description of Project:
The goal of this project is to identify non-enzymatic post-translational modifications in collagen type I that are related to the mechanical properties of human bone and that differ between subjects without osteoporosis and those with a fragility fracture. The project involves specimen preparation, mass spectrometry techniques, mechanical testing and data analysis.

Desired Qualifications:
Experience with MATLAB
Knowledgeable in biomechanics
 
Nature of Supervision:
Will be trained by lab personnel in the various techniques
Will then be independently responsible for achieving the goal of the project
Will meet with lab and PI weekly
 
A Brief Research Plan (period is for 10 weeks):
Prepare specimens for mechanical testing. After testing, extracts proteins for liquid chromatography, tandem mass spectrometry. Submit samples to the mass spectrometry core. Prepare specimens for differential scanning calorimetry and thermal gravimetric analysis. Process data.
 
Number of Open Slots: 1
 
Contact Information:
Name: Jeff Nyman
Department: Biomedical Engineering
Email: jeffry.s.nyman@vanderbilt.edu