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Engineering in vivo gene delivery targeting the kidney

Primary Investigators:
Matthew H. Wilson M.D, Ph.D.
Lauren E. Woodard, Ph.D.
 
Brief Description of Project:
Gene transfer to the kidney remains understudied. This is unfortunate as chronic kidney disease plagues up to 14% of the U.S. population with high morbidity and mortality.  Gene transfer approaches that could cure or limit progression of kidney disease would have high impact on eliminating the widespread mortality and morbidity associated with kidney disease.  This project will focus on testing in vivo gene transfer to the kidney in animal models using engineered nanoparticles and adeno-associated viral (AAV) vectors designed to target specific kidney cell types.

Desired Qualifications:
Our lab personnel will provide the necessary training required for this project. Interest in gene therapy, cell culture techniques, animal models, and biomaterials is desired.
 
Nature of Supervision:
The student will be mentored directly Dr. Wilson, Dr. Woodard (collaborating BME faculty), and a postdoctoral fellow in a genome engineering and translational laboratory located in the Department of Medicine, Division of Nephrology.
 
A Brief Research Plan (period is for 10 weeks):
Our lab is currently testing gene delivery using engineered nanoparticles with capability of targeting specific kidney cell types.  Additionally, we are engineering new AAV vectors capable of targeting the kidney in vivo.  Students will learn about these approaches and test for in vivo delivery, confirmation of transgene expression, and tissue analysis.
 
Number of Open Slots: 1
 
Contact Information:
Name: Matthew H. Wilson
Department: Biomedical Engineering
Email: matthew.wilson@vumc.org