Mechanobiology of the T cell Receptor

Primary Investigators:
Matthew Lang
 
Brief Description of Project:
The T cell receptor is a mechanosensor that utilizes force to detect diseased cells. At the heart of the interaction is a pairing between a variable T Cell receptor and a foreign or modified peptide.  Our lab employs a panel of assays to measure the strength of this interaction under load. This project will involve performing such measurements using optical tweezers and other force probe methods. This project will also involve development of force sensors and methods to assist in calibrations and measurement throughput.

Desired Qualifications:
Familiarity with wet protocols, measurement and instrumentation, programming. Strong work ethic. Creativity and ability to work independently as well as with a team.  An interest in continuing with the project during the academic year is welcomed. The ability to work with collaborators and communicate results is also desired.
 
Nature of Supervision:
Supervision will be through Prof. Lang and his graduate students.
 
A Brief Research Plan (period is for 10 weeks):
Initially the student will learn the ropes of the wet assays and instrumentation. Next the student will be paired with a graduate student shadowing and assisting with measurements. The student will then be given some independent projects to work on such as developing new assays or measurement capabilities.
 
Number of Open Slots: 1
 
Contact Information:
Name: Matthew Lang
Department: Chemical and Biomolecular Engineering
Email: Matt.lang@vanderbilt.edu