Ph.D., Chemical Engineering
B.S., Chemical Engineering
University of Kentucky
Associate Professor of Chemical and Biomolecular Engineering
Associate Professor of Molecular Physiology and Biophysics
Metabolic engineering; systems biology; diabetes, obesity and metabolic disorders; tumor metabolism; autotrophic metabolism; cell culture engineering
Y. Noguchi, J. D. Young, J. O. Aleman, M. E. Hansen, J. K. Kelleher, G. Stephanopoulos. Tracking cellular metabolomics in lipoapoptosis- and steatosis-developing liver cells. Molecular BioSystems 7:1409–19, 2011.
Y. Noguchi, N. Shikata, N. Nishikata, Y. Hara*, J. O. Aleman, J. D. Young, S. Kurihara, N. Koyama, J. K. Kelleher, T. Michio, G. Stephanopoulos. Ketogenic essential amino acids modulate lipid synthetic pathways and prevent hepatic steatosis in mice. PLoS ONE 5: e12057, 2010.
Y. Noguchi, J. D. Young, J. O. Aleman, M. E. Hansen, J. K. Kelleher, G. Stephanopoulos. Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis. Journal of Biological Chemistry 284: 33425–36, 2009.
J. D. Young, K. L. Henne, J. A. Morgan, A. E. Konopka and D. Ramkrishna. Integrating cybernetic modeling with pathway analysis provides a dynamic, systems-level description of metabolic control. Biotechnology and Bioengineering 100:542–59, 2008.
J. D. Young, J. L. Walther, M. R. Antoniewicz, H. Yoo and G. Stephanopoulos. An elementary metabolite unit (EMU) based method of isotopically nonstationary flux analysis. Biotechnology and Bioengineering 99:686–99, 2008.
J. D. Young and D. Ramkrishna. On the matching and proportional laws of cybernetic models. Biotechnology Progress 23:83–99, 2007.
J. D. Young, K. L. Henne, J. A. Morgan, A. E. Konopka and D. Ramkrishna. Cyber-
netic modeling of metabolism: towards a framework for rational design of recombinant organisms. Chemical Engineering Science 59:5041–9, 2004.