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Ethan Lippmann

Assistant Professor of Chemical and Biomolecular Engineering
Assistant Professor of Biomedical Engineering

Chemical and Biomolecular Engineering
Biomedical Engineering (secondary)

Intellectual Neighborhoods

Research Focus

We operate at the intersection of engineering and regenerative medicine with the goal of understanding neurovascular diseases (e.g. disorders that afflict the central nervous system and its surrounding blood vessels) and designing rational therapeutic strategies to combat their progression. Our lab utilizes a diverse spectrum of experimental techniques, including human pluripotent stem cell (hPSC) differentiation, genetic engineering, microscale fabrication and surface modification, and molecular selection/directed evolution. Our immediate focus areas are: 1) the development of representative tissue models using stem cells and engineering techniques; 2) the design and selection of novel targeting agents and signaling pathway modulators; 3) the design of novel small molecule and protein biosensors; 4) coupling our research advancements with existing centers and technologies on campus to develop high throughput systems for drug screening and biological discovery. While we are currently concentrating on the CNS, we anticipate applying our platform technologies to other organ and tissue systems due to the interdisciplinary and highly collaborative environment at Vanderbilt University.

Selected Publications:

Hollmann EK, Bailey AK, Potharazu AV, Neely MD, Bowman AB, and Lippmann ES. “Accelerated differentiation of human induced pluripotent stem cells to blood-brain barrier endothelial cells.” Fluids Barriers CNS 14:9 (2017).

Rosch JC*, Hollmann EK*, and Lippmann ES. “In vitro selection technologies to enhance biomaterial functionality.” Experimental Biology and Medicine 241:962-971 (2016). (* Equal contributions)

Lippmann ES, Williams CE, Ruhl DA, Estevez-Silva MC, Chapman ER, Coon JJ, and Ashton RS. “Deterministic HOX patterning in human pluripotent stem cell-derived neuroectoderm.” Stem Cell Reports 4:632-644 (2015). 

Lippmann ES, Al-Ahmad A, Azarin SM, Palecek SP, and Shusta EV. “A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources.” Scientific Reports 4:4160 (2014). 

Lippmann ES, Estevez-Silva MC, and Ashton RS. “Defined human pluripotent stem cell culture enables highly efficient neuroepithelium derivation independent of small molecule inhibitors.” Stem Cells 32:1032-1042 (2014). 

Lippmann ES*, Azarin SM*, Kay JE, Nessler RA, Wilson HK, Al-Ahmad A, Palecek SP, and Shusta EV. “Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells.” Nature Biotechnology  30:783-791 (2012). (* Equal contributions)