Assistant Professor of Molecular Physiology and Biophysics
Assistant Professor of Biomedical Engineering
Assistant Professor of Pharmacology
Biomedical Engineering (secondary)
A hallmark of life is organisms’ ability to sense and respond to internal and external signals. Our research interests focus on quantitative and predictive understanding of dynamics in signal transduction and regulation of the coding and the non-coding genome related to human health. We are using a cross-disciplinary approach of biology, physics, engineering and computer science by combining quantitative single-molecule experiments in individual cells with genetics and computational biology. Results from this quantitative systems biology research will help to answer key questions in signal transduction and gene regulation of healthy and diseased tissue, and will significantly deepen our understanding of fundamental biophysical and molecular principles in various research fields.
The main research areas in the lab are:
Revolutionize model predictions in human health
2. Develop physiologically relevant cell perturbations to understand biological systems
3. Understand the function of the noncoding genome
Fox Z. Neuert G, Munsky B. Finite State Projection Based Bounds to Compare Chemical Master Equation Models Using Single-Cell Data Journal of Chemical Physics. 2016 Aug;7(145).
Munsky B, Neuert G. From Analog to Digital Gene Regulation Physical Biology. 2015 Jun 18;12(4). 045004 p.
Munsky B, Fox Z, Neuert G. Integrating Single-Molecule Experiments and Discrete Stochastic Models to Understand Heterogeneous Gene Transcription Dynamics. Methods (San Diego, Calif.). 2015 Jun 12.
Neuert G, Munsky B, Tan RZ, Teytelman L, Khammash M, Van Oudenaarden A. Systematic identification of signal-activated stochastic gene regulation. Science (New York, N.Y.). 2013 Feb 1;339(6119). 584-7.
Van Werven FJ, Neuert G, Hendrick N, Lardenois A, Buratowski S, Van Oudenaarden A, Primig M, Amon A. Transcription of two long noncoding RNAs mediates mating-type control of gametogenesis in budding yeast. Cell. 2012 Sep 14;150(6). 1170-81.
Munsky B, Neuert G, Van Oudenaarden A. Using gene expression noise to understand gene regulation. Science (New York, N.Y.). 2012 Apr 13;336(6078). 183-7.
Bumgarner SL, Neuert G, Voight BF, Symbor-Nagrabska A, Grisafi P, Van Oudenaarden A, Fink GR. Single-cell analysis reveals that noncoding RNAs contribute to clonal heterogeneity by modulating transcription factor recruitment. Molecular cell. 2012 Feb 24;45(4). 470-82.
Zimmermann JL, Nicolaus T, Neuert G, Blank K. Thiol-based, site-specific and covalent immobilization of biomolecules for single-molecule experiments. Nature protocols. 2010 Jun;5(6). 975-85.