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Jamey Young

Cornelius Vanderbilt Professor of Engineering
Professor of Chemical and Biomolecular Engineering
Associate Professor of Molecular Physiology and Biophysics
Director of Graduate Studies in Chemical Engineering

Chemical and Biomolecular Engineering

Intellectual Neighborhoods

Research Focus

Metabolic engineering; metabolic flux analysis; diabetes, obesity and metabolic disorders; cancer and immune cell metabolism; photosynthesis research; cell culture engineering

Selected Publications:

  1. Egnatchik, R., Leamy, A., Sacco, S., Cheah, Y., Shiota, M., & Young, J. (2019). Glutamate–oxaloacetate transaminase activity promotes palmitate lipotoxicity in rat hepatocytes by enhancing anaplerosis and citric acid cycle flux. Journal of Biological Chemistry, 294(9), 3081–3090.
  2. Deja, S., Fu, X., Fletcher, J., Kucejova, B., Browning, J., Young, J., & Burgess, S. (2020). Simultaneous tracers and a unified model of positional and mass isotopomers for quantification of metabolic flux in liver. Metabolic Engineering, 59, 1–14.
  3. Hasenour, C., Kennedy, A., Bednarski, T., Trenary, I., Eudy, B., Silva, R., Boyd, K., & Young, J. (2020). Vitamin E does not prevent Western diet-induced NASH progression and increases metabolic flux dysregulation in mice. Journal of Lipid Research, 61(5), 707–721.
  4. Cheah, Y., Xu, Y., Sacco, S., Babele, P., Zheng, A., Johnson, C., & Young, J. (2020). Systematic identification and elimination of flux bottlenecks in the aldehyde production pathway of Synechococcus elongatus PCC 7942. Metabolic Engineering.
  5. Potter, A., Butrico, C., Ford, C., Curry, J., Trenary, I., Tummarakota, S., Hendrix, A., Young, J., & Cassat, J. (2020). Host nutrient milieu drives an essential role for aspartate biosynthesis during invasive Staphylococcus aureus infection. Proceedings of the National Academy of Sciences, 117(22), 12394–12401.
  6. Hasenour, C., Rahim, M., & Young, J. (2020). In Vivo Estimates of Liver Metabolic Flux Assessed by 13C-Propionate and 13C-Lactate Are Impacted by Tracer Recycling and Equilibrium Assumptions. Cell reports, 32(5), 107986. C. C. Hughey, F. D. James, D. P. Bracy, E. P. Donahue, J. D. Young, B. Viollet, M. Foretz, D. H. Wasserman. Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice. Journal of Biological Chemistry 292: 20125–20140, 2017.
  7. B. Faubert, K. Y. Li, L. Cai, C. T. Hensley, J. Kim, L. G. Zacharias, C. Yang, Q. N. Do, S. Doucette, D. Burguete, H. Li, G. Huet, Q. Yuan, T. Wigal, Y. Butt, M. Ni, J. Torrealba, D. Oliver, R. E. Lenkinski, C. R. Malloy, J. W. Wachsmann, J. D. Young, K. Kernstine, R. J. DeBerardinis*. Lactate metabolism in human lung tumors. Cell 171:358–371.e9, 2017.
  8. N. Templeton, K. D. Smith, A. G. McAtee-Pereira, H. Dorai, M. J. Betenbaugh, S. E. Lang, J. D. Young*. Application of 13C flux analysis to identify high-productivity CHO metabolic phenotypes. Metabolic Engineering 43:218–225, 2017.
  9. L. J. Jazmin, Y. Xu, Y. E. Cheah, A. O. Adebiyi, C. H. Johnson, J. D. Young*. Isotopically nonstationary 13C flux analysis of cyanobacterial isobutyraldehyde production. Metabolic Engineering 42:9–18, 2017.
  10. A. K. Leamy, C. M. Hasenour, R. A. Egnatchik, I. A. Trenary, C. Yao, G. J. Patti, M. Shiota, J. D. Young*. Knockdown of triglyceride synthesis does not enhance palmitate lipotoxicity or prevent oleate-mediated rescue in rat hepatocytes. BBA–Molecular and Cell Biology of Lipids 1861:1005–1014, 2016.
  11. Y. M. Whang, S. I. Park, I. A. Trenary, R. A. Egnatchik, J. P. Fessel, J. Kaufman, D. P. Carbone, J.D. Young*. LKB1 deficiency enhances sensitivity to energetic stress induced by erlotinib treatment in non-small cell lung cancer (NSCLC) cells. Oncogene 35:856–866, 2016.