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Kyle Hocking

Biomedical Engineering

Research Focus

    Research Articles

1)     Hocking KM, Brophy C, Rizvi SZ, Komalavilas P, Eagle S, Leacche M, Balaguer JM, Cheung-Flynn J. Detrimental effects of mechanical stretch on smooth muscle function in saphenous veins. J Vasc Surg. 2011 Feb;53(2)

2)     Li FD, Sexton KW, Hocking KM, Osgood MJ, Eagle S, Cheung-Flynn J, Brophy CM, Komalavilas P. Intimal thickness associated with endothelial dysfunction in human vein grafts. J Surg Res. 2013 Mar;180(1)

3)     Osgood MJ, Harrison DG, Sexton KW, Hocking KM, Voskresensky IV, Komalavilas P, Cheung-Flynn J, Guzman RJ, Brophy CM. Role of the renin-angiotensin system in the pathogenesis of intimal hyperplasia: therapeutic potential for prevention of

vein graft failure? Ann Vasc Surg. 2012 Nov;26(8)

4)     Hocking KM, Baudenbacher FJ, Putumbaka G, Venkatraman S, Cheung-Flynn J, Brophy CM, Komalavilas P. Role of cyclic nucleotide-dependent actin cytoskeletal dynamics:Ca(2+)](i) and force suppression in forskolin-pretreated porcine coronary arteries. PLoS One. 2013 Apr 12;8(4)

5)     Bonner JS, Lantier L, Hocking KM, Kang L, Owolabi M, James FD, Bracy DP, Brophy CM, Wasserman DH. Relaxin treatment reverses insulin resistance in mice fed a high-fat diet. Diabetes. 2013 Sep;62(9)

6)     Nelson CE, Kim AJ, Adolph EJ, Gupta MK, Yu F, Hocking KM, Davidson JM, Guelcher SA, Duvall CL. Tunable delivery of siRNA from a biodegradable scaffold to promote angiogenesis in vivo. Adv Mater. 2014 Jan;26

7)     Osgood MJ, Hocking KM, Voskresensky IV, Li FD, Komalavilas P, Cheung-Flynn J, Brophy CM. Surgical vein graft preparation promotes cellular dysfunction, oxidative stress, and intimal hyperplasia in human saphenous vein. J Vasc Surg.

2014 Jul;60(1)

8)     Li FD, Eagle S, Brophy C, Hocking KM, Osgood M, Komalavilas P, Cheung-Flynn J. Pressure control during preparation of saphenous veins. JAMA Surg. 2014 Jul;149(7)

9)     Voskresensky IV, Wise ES, Hocking KM, Li FD, Osgood MJ, Komalavilas P, Brophy C, Cheung-Flynn J. Brilliant blue FCF as an alternative dye for saphenous vein graft marking: effect on conduit function. JAMA Surg. 2014 Nov;149(11)

10)   Sileshi B, Hocking KM, Boyer RB, Baudenbacher FJ, Kohurst KL, Brophy CM, Eagle S. Peripheral venous waveform analysis for detecting early hemorrhage: a pilot study. Intensive Care Med. 2015 Jun;41(6)

11)   Evans BC, Hocking KM, Osgood MJ, Voskresensky I, Dmowska J, Kilchrist KV, Brophy CM, Duvall CL. MK2 inhibitory peptide delivered in nanopolyplexes prevents vascular graft intimal hyperplasia. Sci Transl Med. 2015 Jun 10;7(291)

12)   Evans BC, Hocking KM, Kilchrist KV, Wise ES, Brophy CM, Duvall CL. Endosomolytic Nano-Polyplex Platform Technology for Cytosolic Peptide Delivery To Inhibit Pathological Vasoconstriction. ACS Nano. 2015 Jun 23;9(6)

13)    Wise ES, Ladner TR, Song J, Eagle SS, Mocco J, Wergin JE, Hocking KM, Brophy CM. Race as a predictor of delay from diagnosis to endarterectomy in clinically significant carotid stenosis. J Vasc Surg. 2015 Jul;62(1)

14)   Wise ES, Hocking KM, Brophy CM. Prediction of in-hospital mortality after ruptured abdominal aortic aneurysm repair using an artificial neural network. J Vasc Surg. 2015 Jul;62(1)

15)   Wise ES, Hocking KM, Feldman D, Komalavilas P, Cheung-Flynn J, Brophy CM. An Optimized Preparation Technique for Saphenous Vein Graft. Am Surg. 2015 Jul;81(7)

16)   Wise ES, Hocking KM, Eagle S, Absi T, Komalavilas P, Cheung-Flynn J, Brophy CM. Preservation solution impacts physiologic function and cellular viability of human saphenous vein graft. Surgery. 2015 Aug;158(2)

17)   Wise ES, Gadomski SP 2nd, McMaster WG Jr, Wilson RJ, Nelms JK, Hocking KM, Brophy CM. The influence of VKORC1 and CYP2C9 mutations on warfarin response after total hip and knee arthroplasty. J Orthop. 2015 Nov 28;12

18)   Wise ES, Hocking KM, Kavic SM. Prediction of excess weight loss after laparoscopic Roux-en-Y gastric bypass: data from an artificial neural network. Surg Endosc. 2016 Feb;30(2)

19)   Wise ES, Ahmad S, Ladner TR, Hocking KM, Kavic SM. Impaired weight loss in laparoscopic adjustable gastric banding patients over 50 years of age: diabetes mellitus as an independent risk factor. Surg Endosc. 2016 Feb;30(2)

20)   Wise ES, McMaster WG Jr, Williamson K, Wergin JE, Hocking KM, Brophy CM. Preoperative Predictors of 30-Day Mortality and Prolonged Length of Stay after Above-Knee Amputation. Ann Vasc Surg. 2016 Feb;31

21)   Boyer RB, Hocking KM, Booth GS, Berry JM, Spain TW, Michaels DR, Sandberg WS, Pilla MA. An Evaluation of Induced Failure Modes in the Belmont® Rapid Infuser. Anesth Analg. 2016 Apr;122(4)

22)   Hocking KM, Putumbaka G, Wise ES, Cheung-Flynn J, Brophy CM, Komalavilas P. Papaverine Prevents Vasospasm by Regulation of Myosin Light Chain Phosphorylation and Actin Polymerization in Human Saphenous Vein. PLoS One. 2016 May 2;11(5)

23)   Hocking KM, Luo W, Li FD, Komalavilas P, Brophy C, Cheung-Flynn J. Brilliant blue FCF is a nontoxic dye for saphenous vein graft marking that abrogates response to injury. J Vasc Surg. 2016 Jul;64(1)

24)   Wise ES, Hocking KM, Weltz A, Uebele A, Diaz JJ, Kavic SM, Kligman MD. Red cell distribution width is a novel biomarker that predicts excess body-mass index loss 1 year after laparoscopic Roux-en-Y gastric bypass. Surg Endosc. 2016 Oct;30(10)

25)   Hocking KM, Sileshi B, Baudenbacher FJ, Boyer RB, Kohorst KL, Brophy CM, Eagle SS. Peripheral Venous Waveform Analysis for Detecting Hemorrhage and Iatrogenic Volume Overload in a Porcine Model. Shock. 2016 Oct;46(4)

26)   Wise ES, Hocking KM, Luo W, Feldman DL, Song J, Komalavilas P, Cheung-Flynn J, Brophy CM. Traditional graft preparation decreases physiologic responses, diminishes viscoelasticity, and reduces cellular viability of the conduit: A porcine saphenous vein model. Vasc Med. 2016 Oct;21(5)

27)   Valentine RJ, Boll JM, Hocking KM, Curci JA, Garrard CL, Brophy CM, Naslund TC. Aortic arch involvement worsens the prognosis of type B aortic dissections. J Vasc Surg. 2016 Nov;64(5)

28)   Martin JR, Nelson CE, Gupta MK, Yu F, Sarett SM, Hocking KM, Pollins AC, Nanney LB, Davidson JM, Guelcher SA, Duvall CL. Local Delivery of PHD2 siRNA from ROS-Degradable Scaffolds to Promote Diabetic Wound Healing. Adv Healthc Mater. 2016 Nov;5(21)

29)    Wise ES, Gadomski SP 2nd, Ilg AM, Bermudez C, Chan EW, Izmaylov ML, Gridley SJ, Kaczmarek JV, Melancon SN, Ahmad S, Hocking KM, Diaz JJ, Kavic SM. Independent Preoperative Predictors of Prolonged Length of Stay after Laparoscopic Appendectomy in Patients Over 30 Years of Age: Experience from a Single Institution. Am Surg. 2016 Nov 1;82(11)

30)   Bennett JM, Wise ES, Hocking KM, Brophy CM, Eagle SS. Hyperlactemia Predicts Surgical Mortality in Patients Presenting With Acute Stanford Type-A Aortic Dissection. J Cardiothorac Vasc Anesth. 2017 Feb;31(1)

31)   Pedigo SL, Guth CM, Hocking KM, Banathy A, Li FD, Cheung-Flynn J, Brophy CM, Guzman RJ, Komalavilas P. Calcification of Human Saphenous Vein Associated with Endothelial Dysfunction: A Pilot Histopathophysiological and Demographical Study. Front Surg. 2017 Feb 9

32)   Wise ES, Stonko DP, Glaser ZA, Garcia KL, Huang JJ, Kim JS, Kallos JA, Starnes JR, Fleming JW, Hocking KM, Brophy CM, Eagle SS. Prediction of Prolonged Ventilation after Coronary Artery Bypass Grafting: Data from an Artificial Neural Network. Heart Surg Forum. 2017 Feb 24;20(1)

33)   Wise ES, Wergin JE, Mace EH, Kallos JA, Muhlestein WE, Shelburne NJ, Hocking KM, Brophy CM, Guzman RJ. Upper Extremity Pulse Pressure Predicts Amputation- Free Survival after Lower Extremity Bypass. Am Surg. 2017 Jul 1;83(7)

34)   Wise ES, Hocking KM, Evans BC, Duvall CL, Cheung-Flynn J, Brophy CM. Unregulated saphenous vein graft distension decreases tissue viscoelasticity. Perfusion. 2017 Sep;32(6)

35)   Hocking KM, Alvis BD, Baudenbacher F, Boyer R, Brophy CM, Beer I, Eagle S. Peripheral Intravenous Analysis (PIVA) of Venous Waveforms for Volume Assessment in Patients Undergoing Haemodialysis. British Journal of Anaesthesia 2017 June;119(6):1135-1140. PMID: 29028929.

36)   Hocking KM, Evans BC, Komalavilas P, Cheung-Flynn J, Duvall CL, Brophy CM. Nanotechnology Enabled Modulation of Signaling Pathways Affects Physiologic Responses in Intact Vascular Tissue. Tissue Eng Part A. 2019 Mar;25(5-6)

37)   Miles M, D Alvis BD, Hocking K, Baudenbacher F, Guth C, Lindenfeld J, Brophy C, Eagle S. Peripheral Venous Waveform Analysis (PIVA) Predicting Hospital Readmission for Acute Heart Failure. Journal of Cardiac Failure 2018 May;24(8):525-532. PMID: 29777760.

38)   Hernando D, McCallister R, Lazaro J, Hocking K, Gil E, Laguna P, Alvis BD, Brophy C, Bailon R. Validity of Venous Waveform Signal for Heart Rate Variability Monitoring. Computing in Cardiology by IEEE 2018 September;45.

39)   Hernando D, Nardelli M, Hocking K, Lazaro J, Alvis B, Gil E, Scilingo EP, Brophy DR, Valenza G, Laguna P, Brophy C, Bailon R. Effect of Yoga on Pulse Rate Variability Measured from a Venous Pressure Waveform. Conf Proc IEEE Eng Med Biol Soc. 2019 July;372-375. PMID: 31945918.

40)   Cheung-Flynn J, Alvis BD, Hocking KM, Guth CM, Luo W, McCallister R, Chadalavada K, Polcz M, Komalavilas P, Brophy CM. Normal Saline Solutions Cause Endothelial Dysfunction Through Loss of Membrane Integrity, ATP Release, and Inflammatory Responses Mediated by P2X7R/p38 MAPK/MK2 Signaling Pathways. PLoS One 2019 August;14(8) PMID: 31412063 PMCID: PMC6693757.

41)   Alvis BD, Polcz MP, Huston JH, Hopper TS, Leisy P, Mishra K, Eagle SS, Brophy CM, Lindenfeld J, Hocking KM. Observational Study of Non-Invasive Venous Waveform Analysis (NIVA) to Assess Intracardiac Filling Pressures during Right Heart Catheterization. Journal of Cardiac Failure 2019 September;26(2):136-141. PMID: 31574315.

42)   Alvis BD, McCallister R, Polcz M, Lima JLO, Sobey JH, Brophy DR, Miles MR, Brophy C, Hocking K. Non-Invasive Venous Waveform Analysis (NIVA) for Monitoring Blood Loss in Human Blood Donors and Validation in a Porcine Hemorrhage Model. J Clin Anesth 2019 November;61(109664) PMID: 31786067.

43)   Nally MC, Kling C, Hocking KM, Lillemoe H, Boll JM, Curci JA, Garrard CL, Naslund TC, Valentine RJ. Follow-up imaging of traumatic vertebral artery dissections is unnecessary in asymptomatic patients. Journal of Vascular Surgery 2019 June;69(6) PMID: 30792055.

44)   Alvis BD, Polcz M, Miles M, Wright D, Shwetar M, Leisy P, Forbes R, Fissell R, Whitfield J, Eagle S, Brophy C, Hocking K. Non-invasive venous waveform analysis (NIVA) for volume assessment in patients undergoing hemodialysis: an observational study. BMC Nephrology 2020 May;21(1) PMID: 32448178.

45)   Sobey JH, Reddy SK, Hocking KM, Polcz ME, Guth CM, Schlegel C, Whitfield J, Eagle SS, Brophy CM, Alvis BD. Non-Invasive Venous waveform Analysis (NIVA) for volume assessment during complex cranial vault reconstruction: A proof-of-concept study in children. PLOS One 2020 July;8(15):30-35. PMID: 32640004.

46)   Polcz M, Hocking KM, Chang D, Leisy P, Sobey JH, Huston J, Eagle S, Brophy C, Alvis BD. A brief report on the effects of vasoactive agents on peripheral venous waveforms in a porcine model. JRSM Cardiovascular Disease 2020 August;9:1-5.

47)   Wise ES, Hocking KM, Polcz ME, Beilman GJ, Brophy CM, Sobey JH, Leisy PH, Kiberenge RK, Alvis BD. Hemodynamic Parameters in the Assessment of Fluid Status in a Porcine Hemorrhage and Resuscitation Model. Anesthesiology 2021 February; PMID: 33635950.

48)   Bret Alvis, Jessica Huston, Jeffery Schmeckpeper, Monica Polcz, Marisa Case, René Harder, Jonathan S Whitfield, Kendall G Spears, Meghan Breed, Lexie Vaughn, Colleen Brophy, Kyle M Hocking, JoAnn Lindenfeld. Non-Invasive Venous waveform Analysis (NIVA) correlates with pulmonary capillary wedge pressure (PCWP) and predicts 30-day admission in heart failure patients undergoing right heart catheterization: NIVA Scores correlate with PCWP and predicts 30-day admission. Journal of Cardiac Failure 2021 September; PMID: 34555524.

49)   Alvis, Bret MD; Vaughn, Lexie MD; Schmeckpeper, Jeffrey MD, PhD; Huston, Jessica MD; Case, Marisa RN; Semler, Matthew MD; Lindenfeld, JoAnn MD; Brophy, Colleen MD; Hocking, Kyle PhD. Respiratory Non-Invasive Venous Waveform Analysis for Assessment of Respiratory Distress in Coronavirus Disease 2019 Patients: An Observational Study. Critical Care Explorations 2021 October; PMID: 34617035 PMCID: PMC8489896.

50)   Sobey JH, Menser CC, Hartzog AJ, Hocking KM, Niconchuk JA, Bonfield CM, Stricker PA, Reddy SK. Antifibrinolytics Are Not Associated With Reduced Blood Loss in Minimally-Invasive Endoscopic-Assisted Craniectomy for Repair of Single-Suture Craniosynostosis. Journal of Craniofacial Surgery 2021 November; 10.

51)   Monica Polcz, Jessica Huston, Meghan Breed, Marisa Case, Philip Leisy, Jeffrey Schmeckpeper, Lexie Vaughn, Jenn Helmer Sobey, Colleen Brophy, JoAnn Lindenfeld, Kyle Hocking, Bret Alvis. Comparison of clinical symptoms and bioimpedance to pulmonary capillary wedge pressure in heart failure. American Heart Journal Plus: Cardiology Research and Practice 2022 March;15.


1. Alvis BD, Huston JH, Lindenfeld J, Hocking KM. Author Response to Imamura and Narang. J Card Fail 2019 November;26(1):96-96. PMID: 31765693.