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Seth Smith

Professor of Radiology and Radiological Sciences
Professor of Biomedical Engineering
Professor of Ophthalmology
Associate Director, VUIIS
Director of the Center for Human Imaging

Biomedical Engineering

Research Focus

Development of advanced MRI methods for the detection and quantification of pathologies affecting the spinal cord and optic nerve

Center for Human Imaging


1.         Sengupta S, Smith DS, Smith AK, Welch EB, Smith SA. Dynamic Imaging of the Eye, Optic Nerve and Extraocular Muscles with Golden Angle Radial MRI. Investigative Ophthalmology and Visual Science Aug 1;58(10):4390-4398 (2017). PMCID:  PMC5559179

2.         By S, Barry RL, Smith AK, Dula AN, Lyttle BD, Bagnato F, Pawate S, Smith SA. APT CEST of the Spinal Cord in Multiple Sclerosis Patients at 3T. Magn Reson Med. 2018 Feb;79(2):806-814. PMCID: PMC5777527

3.         By S, Zu J, Box BA, Bagnato FR, Smith SA. Multi-Compartment Microscopic Diffusion Characterization of the Cervical Spinal Cord. NMR Biomed 2018 Apr;31(4):e3894. PMCID: PMC5854548

4.         Conrad BN, Barry RL, Rogers BP, Maki S, Mishra A, Thukral S, Sriram S, Bhatia A, Pawate S, Gore JC, Smith SA. Multiple Sclerosis Lesions Affect Intrinsic Functional Connectivity of the Spinal Cord. Brain 2018 Jun 1;141(6):1650-1664. PMCID: PMC5972586

5.         Dortch RD, Bagnato FM, Gochberg DF, Gore JC, Smith SA. Optimization of Selective Inversion Recovery Magnetization Transfer Imaging for Macromolecular Content Mapping in the Human Brain. MRM 2018 Nov;80(5): 1824-1835. PMCID: PMC6107392 


6.         O’Grady KP, Dula AN, Lyttle BD, Thompson LM, Conrad BN, Box BA, McKeithan LJ, Pawate S, Bagnato FR, Landman BA, Newhouse P, Smith SA. Glutamate-sensitive imaging and evaluation of Cognitive Impairment in Multiple Sclerosis. Mult Scler. 2019 Dec;203:116190 PMCID: PMC6424643

7.         Barry RL, Conrad BN, Smith SA, Gore JC. A Practical Protocol for Measurements of Spinal Cord Functional Connectivity. Sci Rep. 2019 Nov 8;8(1):16512. PMCID: PMC6224587.

8.     Gros C, De Leener B, et al. Automatic Segmentation of the Spinal Cord and Intramedullary Multiple Sclerosis Lesions with Convolutional Neural Networks. Neuroimage 2019 Jan 1: 184:901-0915. PMCID: PMC6759925

9.     McKeithan LJ, Lyttle BD, Box BA, O’Grady KP, Dortch RD, Conrad BN, Thompson LM, Rogers BP, Newhouse P, Pawate S, Bagnato FR, Smith SA. 7T Quantitative Magnetization Transfer (qMT) of Cortical Gray Matter in Multiple Sclerosis Correlates with Cognitive Impairment. NeuroImage 2019 Dec;203:116190.  PMCID: PMC7549401

10.     Reynolds BB, By S, Weinberg QR, Witt AA, Newton AT, Feiler HR, Ramkorun B, Clayton DB, Couture P, Martus JE, Adams, M, Wellons III JC, Smith SA, Bhatia A. Quantification of DTI in the Pediatric Spinal Cord: Application to Clinical Evaluation in Normal Patient Population. AJNR 2019 Jul; 40(7):1236-1241. PMCID: PMC7048550

11.     Schilling KG, By S, Feiler HR, Box BA, O'Grady KP, Witt AA, Landman BA, Smith SA. Diffusion MRI microstructural models in the cervical spinal cord – application, normative values, and correlations with histological analysis. NeuroImage 2019 Jul19;201:116026. PMCID: PMC6765439

12.     Chaganti S, Welty V, Taylor W, Albert K, Failla M, Cascio C, Smith SA, Mawn LA, Bagnato FM, Lasko T, Blume J, Landman BA. Discovering Novel Disease Comorbidities Using Electronic Medical Records. PLoS One 2019 Nov 27;14(11):e0225495. PMCID: PMC6880990

13.     Bagnato FR, Gauthier SA, Laule C, Moore GRW, Bove R, Cai Z, Cohen-Adad J, Harrison DM, Klawaiter EC, Morrow SA, Öz G, Rooney WD, Smith SA, NAIMS Cooperative. Imaging Mechanisms of Disease Progression in Multiple Sclerosis: Beyond Brain Atrophy. J Neuroimaging 2020 May;30(3):251-266.  doi: 10.1111/jon.12700.

14.     Barry RL, Conrad BN, Maki S, Watchmaker JM, McKeithan LJ, Box BA, Weinberg QR, Smith SA† and Gore JC†. Multi-shot Acquisitions for Stimulus-evoked Spinal Cord BOLD fMRI. MRM 2021 Apr;85(4):2016-2026. PMCID: PMC7775356

15.     Clarke MA, Lakhani DA, Wen S, Gao S, Smith SA, Dortch RD, Xu J, Bagnato F. Perilesional neurodegenerative injury in Multiple Sclerosis: Relation to Focal Lesions and Impact on Disability. Mult Scler Relat Disord. 2021 Apr; 49:102738. PMCID: PMC8381285

 16.     Cohen-Adad J, Alonso-Ortiz E, … Smith SA…Xu J. Generic Acquisition Protocol for Quantitative MRI of the Spinal Cord. Nature Protocols. 2021 Oct;16(10):4611-4632. PMCID: PMC8811488

17.     O’Grady KP, Satish S, Owen QR, Box BA, Bagnato FR, Combes AJE, Cook SR, Westervelt H, Feiler HR, Lawless RD, Sarma A, Malone SD, Ndolo JM, Yoon K, Dortch RD, Rogers BP, Smith SA. Relaxation-compensated chemical exchange saturation transfer MRI in the brain at 7T: application in relapsing-remitting multiple sclerosis. Frontiers of Neurol, 22 Feb 25;13:764690. PMCID: PMC8923037

18.     Zhou J, Zaiss M, Knutsson, Sun PZ, … Smith SA …, van Zijl PCM. Review and consensus recommendations on clnical APT-weighted imaging approaches at 3T: Application to brain tumors. MRM epub ahead of print (4/2022).

19.    Combes AJE, O’Grady KP, Rogers BP, Schilling KG, Lawless RD, Visagie M, Houston D, Prock LE, Malone S, Satish S, Witt AA, McKnight CD, Bagnato FR, Gore JC, Smith SA. Functional connectivity in the dorsal network is correlated with diffusion tensor imaging indices in the cervical spinal cord in relapsing-remitting multiple sclerosis. NeuroImage Clinical. 2022 Jul 27;35:103127. PMCID: PMC9421501

20.     Schilling KG, Palombo M, O’Grady KP, Combes AJE, Anderson AW, Landman BA, Smith SA. Minimal number of sampling direction for robust measurement of spherical mean diffusion weighted signal: effects of sampling directions, b-value, signal-to-noise ratio, hardware and fitting strategy. MRI 2022 Aug 2;94:25-35. DOI: 10.1016/j.mri.2022.07.015